MEDICINAL ORGANIC CHEMISTRY GROUP

The Medicinal Organic Chemistry (MOC) Group is delighted to celebrate an important milestone as Oliviero Cini successfully defended his PhD thesis, co-supervised by Professor Maria M. M. Santos. Over the course of his PhD journey, Oliviero has demonstrated outstanding dedication, scientific curiosity, and perseverance. His research has made valuable contributions to our group's scientific endeavors, and his commitment to advancing medicinal chemistry has been truly inspiring.

We are delighted to announce the publication of our latest review article, "Drugging p53 mutants: Recent advances using small-molecule modulation strategies," in the European Journal of Medicinal Chemistry. This review provides a comprehensive overview of recent advances in targeting mutant p53 proteins through small-molecule modulation strategies. It explores the molecular mechanisms behind these approaches, highlights the key discoveries that have shaped the field, and disc

The Medicinal Organic Chemistry (MOC) Group is proud to celebrate a remarkable milestone as Israa Al jnadi successfully defended her PhD thesis under the supervision of Professor Alexandra Paulo. Throughout her PhD journey, Israa has demonstrated exceptional dedication, scientific excellence, and resilience. Her commitment to advancing research and her invaluable contributions to our group have left a lasting impact on both our science and our team. As Israa embarks on the ne

The MOC Group was proudly represented at the XVII iMed.ULisboa Meeting held in Lisbon on 23–24 June, where several of our students showcased their research through scientific poster presentations. In addition to the poster presentations, Tiago Delgado delivered an oral presentation, sharing key findings from his PhD. Their contributions provided valuable opportunities for scientific discussion and networking. We congratulate all participants for their excellent contributions

We congratulate Tomás G. Monteiro, who won the Honourable Mention in the Portuguese Award for Best Master Thesis in Medicinal Chemistry & Chemical Biology 2025.

We are pleased to mark the Professorial Aggregation of our group leader, Professor Maria Santos. This important academic milestone recognizes her distinguished career in teaching, research, and service to the academic community. Throughout her career, Professor Maria Santos has made significant contributions to advancing knowledge in the p53 research field, inspiring and mentoring generations of students and researchers with dedication and academic rigor. We warmly congratula

Amelia Oszczyk is an Erasmus Master's student intern from the Jagiellonian University Collegium Medicum (Krakow, Poland). She will be working on the synthesis of MDM2-based PROTACs for selective degradation of mutant p53 as part of the project PROTAC4OncoP53.

Francesco Napolitano joins the laboratory as an Erasmus Intern from Università degli studi di Salerno (Salerno, Italy). He will be working on the synthesis of VHL-based PROTACs for selective degradation of mutant p53 as part of the project PROTAC4OncoP53.

We are pleased to congratulate Inês Domingues and Tomás G. Monteiro on the successful defense of their Master theses and the completion of their Master degrees. This achievement marks the culmination of a demanding academic journey, reflecting their dedication, commitment, and academic rigor. We extend our sincere congratulations to both graduates and wish them continued success in their future academic and professional endeavors. May this milestone be the beginning of many f

We are honored that Tomás Ginestal has won a €50 prize for poster presentation at this year’s AEFFUL conference! 🎉 Tomás shared the results of his Master's project in a poster presentation , showcasing the valuable work being conducted as part of TRYP4MUTP53 project. Congratulations on a great presentation! A huge thank-you to the organizers and everyone who stopped by to discuss his work.

We are delighted to announce that four of our team members participated actively in the XXIX Encontro Luso‑Galego de Química , held in Braga, Portugal from 10–12 November 2025. Ricardo Ferreira delivered an oral presentation about the state of the art and results of the new granted project title PROTAC4OncoP53. Tiago Delgado presented his master results about novel DprE1 inhibitors in the oral session. Bárbara Bahls contributed with another oral presentation on her results of

We would like to inform you that Notice No. TI/4/FARM-ID/2025, regarding the Recruitment and Selection of a Research Technician within...

We are excited to announce that our new paper, “Batch and Continuous Synthesis of 5,5-Diphenylhydantoin, an Active Pharmaceutical...

We are delighted to welcome the newest members of our research group - Alexandre Charneca, João Matias, Kely Werneck, Margarida Fernandes! This year, we are joined by a group of students who bring fresh perspectives, curiosity, and enthusiasm to our work. Each of them will contribute to ongoing projects while developing their own scientific path within the group. We are excited to support their growth, celebrate their achievements, and work together toward new discoveries. To

We are pleased to inform that a new paper entitled " Hybrid Molecules of p53 Activators and Protoflavones to Target Multiple Myeloma " ...

Ricardo J.F. Ferreira represented our research group at the 12th edition of the EFMC Young Medicinal Chemists' Symposium (EFMC-YMCS...

Our research group was proudly represented by our group leader at the 10th edition of the International Symposium on Advances in...

In 1 and 2 of July, Ricardo Ferreira, Tiago Delgado, Israa Al-Jnadi, Tomás Monteiro, and Mohsin Iqbal presented their poster at the XVI...

Our PhD student Bárbara preseted her latest results about G4 binding molecules on a poster at Protein Electrostatics Conference 2025 in...

Bárbara Bahls was at 5th Meeting of Young Biophysicists, 8-9 of May in FCT-Nova, presenting a flash talk on our latest results in the...