New Research Article Accepted for Publication in ACS Medicinal Chemistry Letters

We are pleased to announce that a new research article involving members of the MOC group has been accepted for publication in ACS Medicinal Chemistry Letters.

The article, entitled “Discovery of a Novel Chemical Scaffold for Dual MDM2 and MDM4 Inhibition”, reports the discovery of a novel chemical scaffold targeting both MDM2 and MDM4, two important proteins involved in the regulation of the tumour suppressor protein p53. The development of compounds capable of simultaneously inhibiting these targets represents a promising strategy in the search for new anticancer therapeutic approaches.

The work brings together an international team of researchers, including Elizabeth A. Lopes, Ricardo J. F. Ferreira, Joana D. Amaral, Mi Wang, Saad Shaaban, Shaomeng Wang, Nuno Maulide, Cecilia M. P. Rodrigues, Daniel J. V. A. dos Santos, and Maria M. M. Santos.

We warmly congratulate all the authors on this achievement and are proud to see this collaborative research contributing to the discovery and development of new chemical strategies with potential applications in cancer therapy.

Congratulations to the entire team!