New paper accepted on ACS Pharmacology & Translational Science
- medorglab
- 24 de abr.
- 1 min de leitura
Atualizado: há 3 dias
Our latest paper was accepted today in ACS Pharmacology & Translational Science, reporting a small molecule that stabilizes both wild-type and R273H mutant p53. The compound selectively reacts with Cys141 via nucleophilic aromatic substitution, highlighting a novel covalent activator for targeting p53.
![MedOrgChem group represented at the EURESTOP Meeting [CA21145] in Seville](https://static.wixstatic.com/media/008050_308e2bb934664ac8aa26fe10aa76560d~mv2.jpg/v1/fill/w_980,h_663,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/008050_308e2bb934664ac8aa26fe10aa76560d~mv2.jpg)
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